Efficacy has been demonstrated by extensive clinical trails to confirm it treats skin and gill flukes including all the resistant strains of fluke (where other treatments have failed) it ca also treat Trichodina, Costia, Tapeworms, Round worms and crustaceans such as Argulus(fish lice). It can be used in the presence of salt. it uses the same proprietary technology as the Fluke Solve range so the method of administration is the same - simply rip, tip and stir. However in the case of gill flukes which lay eggs as with previous products a second treatment is recommend after 3 weeks to break the flukes life cycle